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NCI Drug Dictionary

  

recombinant human hyaluronidase 
A human recombinant form of the naturally occurring human enzyme hyaluronidase with potential chemoadjuvant activity. Upon local administration, recombinant human hyaluronidase hydrolyzes hyaluronic acid, a glucosaminoglycan responsible for the viscosity of the interstitial barrier. The digestion of hyaluronic acid lowers the viscosity in the interstitial space, thereby increasing permeability and facilitating local penetration of chemotherapeutic agents into cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Chemophase
Abbreviation:rHuPH20