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NCI Drug Dictionary

  

Seneca Valley virus-001 
A native, replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 (SVV-001) specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:NTX-010
SVV-001