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NCI Drug Dictionary


berubicin hydrochloride 
The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:topoisomerase II inhibitor RTA 744
Code name:RTA 744
Chemical structures:(8S,10S)-10-[(3-amino-4-O-benzyl-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]- 6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene- 5,12-dione hydrochloride
5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L- lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-