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The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||topoisomerase II inhibitor RTA 744|
|Code name:||RTA 744|
|Chemical structures:||(8S,10S)-10-[(3-amino-4-O-benzyl-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]- 6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene- 5,12-dione hydrochloride |
5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L- lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-