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NCI Drug Dictionary


siRNA-expressing SV40 vector 
A simian virus 40 (SV40)-based shuttle vector, encoding small interfering RNA (siRNA), with potential antineoplastic activity. The expression of siRNA in target tumor cells transfected with an siRNA-expressing SV40 vector may result in siRNA-mediated silencing of target oncogenes and, so, the inhibition of tumor cell growth and the induction of tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)