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NCI Drug Dictionary


dapsone gel, 5% 
A gel containing 5% (w/w) dapsone, a synthetic derivative of diamino-sulfone with anti-infective properties. A structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Aczone Gel