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The sodium salt form of tasisulam, an acyl-sulfonamide compound with potential antiproliferative activity. Tasisulam activates, through an as of yet not fully elucidated mechanism, the intrinsic mitochondrial-mediated cell death pathway as manifested by decreased adenosine triphosphate (ATP), cytochrome C release, activation of caspases, loss of mitochondrial membrane potential, production of reactive oxygen species (ROS) and eventually apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Chemical structure:||benzamide, N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro-, sodium salt|