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NCI Drug Dictionary

  

WT-1 analogue peptide vaccine 
A peptide vaccine containing a human Wilms tumor 1 (WT-1) protein-derived epitope with potential antineoplastic activity. Vaccination with the WT-1 analogue peptide vaccine may induce a cytotoxic T-lymphocyte (CTL) response against WT-1 expressing cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. WT-1, a zinc finger transcription factor, is overexpressed in most types of leukemia and in some solid cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:WT-1 vax