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sevoflurane
A fluorinated isopropyl ether with general anesthetic activity. Although the mechanism of action has not been fully elucidated, sevoflurane may interfere with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. This agent may also interact directly with the lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, sevoflurane may activate gamma-aminobutyric acid (GABA) receptors, hyperpolarizing cell membranes and resulting in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure, and an increased respiratory rate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Ultane | |
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| Chemical structures: | | 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- | |
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