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NCI Drug Dictionary

NCI Drug Dictionary

  

sevoflurane 
A fluorinated isopropyl ether with general anesthetic activity. Although the mechanism of action has not been fully elucidated, sevoflurane may interfere with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. This agent may also interact directly with the lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, sevoflurane may activate gamma-aminobutyric acid (GABA) receptors, hyperpolarizing cell membranes and resulting in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure, and an increased respiratory rate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Ultane
Chemical structures:1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-