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NCI Drug Dictionary


cell cycle checkpoint/DNA repair antagonist IC83 
A proprietary agent with potential antineoplastic activity. Cell cycle checkpoint/DNA repair antagonist IC83 IC83 inhibits cell cycle checkpoint/DNA repair enzymes, which may result in enhanced cytotoxicity of DNA damaging agents and diminished tumor cell resistance to chemotherapy and radiation therapy. Cell cycle checkpoint/DNA repair enzymes are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:IC83