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NCI Drug Dictionary


eicosapentaenoic acid 
An essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:all cis-5,8,11,14,17-eicosapentaenoic acid
icosapentaenoic acid
timnodonic acid