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NCI Drug Dictionary


teglarinad chloride 
A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:apoptosis inducer GMX1777
Code name:GMX1777
Chemical structures:4-({N-[6-(4-chlorophenoxy)hexyl]-N'-cyanocarbamimidoyl}amino)-1-(3-oxo- 2,4,7,10,13,16-hexaoxaheptadecan-1-yl)pyridinium chloride
pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride