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NCI Drug Dictionary


glycosylated recombinant human G-CSF AVI-014 
A glycosylated form of a recombinant agent that is chemically identical to or similar to endogenous human granulocyte colony-stimulating factor (G-CSF) and is produced using transgenic biotechnology. Transgenic hens carrying recombinant human G-CSF cDNA express the naturally glycosylated recombinant human protein in egg albumen from which glycosylated recombinant human G-CSF AVI-014 is isolated. Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:glycosylated rhG-CSF AVI014
Code name:AVI-014