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NCI Drug Dictionary


A highly specific, synthetic peptide vascular endothelial growth factor receptor-2 (VEGFR-2) antagonist with potential antiangiogenic activity. Derived from human fibronectin with a proprietary protein engineering process, pegdinetanib may block the activation of VEGFR-2 by all known activating ligands, thereby inhibiting the growth of new tumor blood vessels. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:VEGFR-2 inhibitor peptide CT-322
US brand name:Angiocept
Code name:CT-322