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NCI Drug Dictionary


fluorine F 18 fluciclovine 
A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluorine F 18 fluciclovine ([18]FACBC) appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occuring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, [18]FACBC accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:anti-1-amino-3-[18F ]fluorocyclobutane-1-carboxylic acid
fluciclovine (18F)