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NCI Drug Dictionary


retinoid analogue NRX 195183 
An orally bioavailable retinoid acid receptor (RAR) alpha agonist with potential antineoplastic activity. Retinoid analogue NRX 195183 binds to and activates RAR alpha, modulating the transcription of genes responsible for cell differentiation and proliferation, which may result in cell differentiation, decreased cell proliferation, and the inhibition of tumorigenesis. Encoded by the RARA gene, RAR alpha is a nuclear receptor and a member of the steroid receptor superfamily. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:retinoid acid receptor alpha agonist NRX 195183
Abbreviation:RAR alpha agonist NRX 195183
Code name:NRX 195183