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NCI Drug Dictionary


A monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Ficlatuzumab binds to the soluble ligand HGF, preventing the binding of HGF to its receptor c-Met and activation of the HGF/c-Met signaling pathway, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:anti-HGF monoclonal antibody SCH900105
Code names:AV-299
SCH 900105