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NCI Drug Dictionary


FAK inhibitor PF-04554878 
An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:focal adhesion kinase inhibitor PF-04554878
Code name:PF-04554878