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NCI Drug Dictionary


adenosine A3 receptor agonist CF102 
An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:A3AR agonist CF102
Code name:CF102
Chemical structure:2-chloro-N6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)--D-ribofuranosyl]adenine