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NCI Drug Dictionary

NCI Drug Dictionary

  

lutetium Lu 177-DOTA-di-HSG peptide IMP-288 
A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide lutetium (Lu) 177. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered Lu-177-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; Lu-177 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized scintigraphically. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Lu-177-labeled di-histamine-succinyl-glycine-DOTA peptide IMP-288