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NCI Drug Dictionary


human trefoil factor 1-secreting Lactococcus lactis AG013 
An oral rinse solution containing a strain of the bacteria Lactococcus lactis (L. lactis) genetically modified to express human Trefoil Factor 1 (hTFF1) with potential cytoprotective activity. With oral rinsing, human trefoil factor 1-secreting Lactococcus lactis AG013 may secrete and deliver hTFF1 to oral mucosal tissue, protecting or promoting the healing of damaged oral mucosa. hTFF1, a peptide belonging to the Trefoil factors family (TFF), is normally secreted by mucous epithelia and is involved in protecting mucosal tissue and maintaining mucosal surface integrity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:hTFF1-secreting Lactococcus lactis AG013
Code name:AG013