Español
Questions About Cancer? 1-800-4-CANCER
  • Print
  • Facebook
  • Twitter
  • Google+
  • Pinterest

NCI Drug Dictionary

  

technetium Tc 99m demobesin-4 
A radioconjugate composed of the synthetic bombesin (BB) analog demobesin-4 bound to the radioisotope technetium Tc 99m with receptor ligand and gamma-emitting radioisotope activities. Upon intravenous administration, demobesin-4 selectively binds to the gastrin-releasing peptide receptor (GRPR) expressed on the surfaces of various tumor cell types; upon internalization, tumor cells expressing GRPRs bound to technetium Tc 99m can then be visualized using scintigraphy. GRPR, a bombesin receptor subtype, is frequently overexpressed on the surface of tumor cells such as prostate and breast cancer cells. Demobesin-4 was developed for technetium Tc 99m imaging of GRPR-expressing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:99mTc demobesin-4