NCI Drug Dictionary
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allogeneic cytomegalovirus-specific cytotoxic T lymphocytes
A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon immunoprophylactic adoptive cell therapy infusion with allogeneic cytomegalovirus-specific cytotoxic T lymphocytes, these CTLs may help reconstitute CMV-specific CTL responses in CMV-infected immunocompromised hosts after allogeneic hematopoietic stem cell transplant, thereby potentially preventing the occurrence of CMV viral disease or reducing the amount of antiviral drug therapy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Abbreviation:||allogeneic CMV-specific CTLs|