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NCI Drug Dictionary

  

live-attenuated Listeria monocytogenes cancer vaccine ADXS11-001 
A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination, Listeria expresses the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:attenuated live Listeria encoding HPV 16 E7 vaccine ADXS11-001
US brand name:Lovaxin C
Code names:ADXS11-001
Lm-LLO-E7