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NCI Drug Dictionary

NCI Drug Dictionary

  

iodine I 131 anti-fibronectin antibody fragment L19-SIP 
An iodine 131 radioimmunoconjugate of a small immunoprotein (SIP), derived from the variable region fragment of human monoclonal antibody L19, that is directed against the extra-domain B (ED-B) of fibronectin, with potential radioimmunotherapeutic activity. The SIP moiety of iodine I 131 anti-fibronectin antibody fragment L19-SIP binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. Upon internalization, the I 131 radionuclide may selectively detect or deliver cytotoxic radiation to fibronectin-expressing tumor cells. ED-B of fibronectin, a naturally occurring marker of tissue remodeling and angiogenesis, is expressed in the majority of aggressive solid human tumors, whereas it is not detectable in normal vessels and tissues. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:I-131 antibody L19-SIP
Abbreviation:I-131 L19-SIP
Code name:L19-SIP