NCI Drug Dictionary
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liposome-incorporated Grb2 antisense oligodeoxynucleotide
A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein involved in growth signaling pathways, is upregulated in certain tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||grb2 mRNA |
liposomal Grb2 AS ODN