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NCI Drug Dictionary


tiotropium bromide monohydrate 
The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Spiriva
Chemical structures:1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid
6.Beta.,7.Beta.-Epoxy-3.Beta.-Hydroxy-8-Methyl-1.Alpha.H,5.Alpha.H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate