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NCI Drug Dictionary


trientine hydrochloride 
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:triethylenetetramine dihydrochloride
US brand name:spyrine
Chemical structure:N,N'-bis(2-aminoethyl)ethane-1,2-diamine