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NCI Drug Dictionary

  

poziotinib 
An orally bioavailable, quinazoline-based, mall-molecular and irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. Poziotinib inhibits EGFR (HER1 or ErbB1), HER2, HER4 and EGFR mutants, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:pan-HER kinase inhibitor HM781-36B
Code names:HM781-36B
NOV120101