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NCI Drug Dictionary


oral aminolevulinic acid hydrochloride 
A powder for an oral solution comprised of the hydrochloride salt of 5-aminolevulinic acid (ALA) with a potential application for photodynamic therapy. After oral administration, ALA is converted intracellularly into the photosensitizer protoporphyrin IX (PpIX). Upon exposure to light of appropriate wavelength (violet to blue range), excited PpIX emits a characteristic red fluorescence which could facilitate guided resection, and generates excited singlet oxygen molecules that could kill cells when appropriate laser dosage is applied. ALA is preferentially taken up by and accumulates in many types of cancer cells compared to normal, healthy cells. Consequently, cancer cells can be visualized and can be distinguished from normal, healthy cells. Check for active clinical trials or closed clinical trials using this agent.
Synonym:5-aminolevulinic acid hydrochloride, oral
Foreign brand name:Gliolan
Abbreviation:oral 5-ALA