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NCI Drug Dictionary


indium In 111 anti-CD45 monoclonal antibody BC8 
A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb) BC8 labeled with the gamma-emitting isotope indium 111 (In 111), with potential radioimaging application. Upon administration, indium In 111 anti-CD45 monoclonal antibody BC8 binds to CD45 antigen, a receptor protein tyrosine phosphatase expressed on the surface of most of the normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, radioactive In 111 allows for the detection of BC8 distribution and tumor localization using gamma scintigraphy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:In 111 MOAB BC8
In 111 monoclonal antibody BC8
In111 MOAB BC8
indium In 111 MOAB BC8