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NCI Drug Dictionary


monocarboxylate transporter 1 inhibitor AZD3965 
An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity. Upon oral administration, MCT1 inhibitor AZD3965 binds to MCT1 and prevents the transport of lactate into and out of the cell. This leads to an accumulation of lactate, intracellular acidification, and eventually cancer cell death. MCT1, a protein overexpressed on tumor cells, is responsible for the transport of monocarboxylates across the cell membrane and plays a key role in cell metabolism. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:MCT1 inhibitor AZD3965
Code name:AZD3965