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NCI Drug Dictionary

NCI Drug Dictionary

  

phenprocoumon 
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Liquamar
Chemical structures:2H-1-benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-
3-(alpha-phenylpropyl)-4-hydroxycoumarin