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NCI Drug Dictionary


cyclobenzaprine hydrochloride 
A centrally acting muscle relaxant, chemically similar to amitriptyline hydrochloride with antidepressant activity. The exact mechanism of action of cyclobenzaprine hydrochloride has not been fully determined. However, it primarily acts at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons. This leads to a reduction in muscle spasms. Check for active clinical trials or closed clinical trials using this agent.
US brand names:Cycloflex
Code name:FR2100873
Chemical structures:10,11delta-amitriptyline hydrochloride
1-propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride