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NCI Drug Dictionary


recombinant human serum amyloid P/pentraxin 2 
A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid P/pentraxin 2 (PRM-151) may inhibit myofibroblast generation by preventing the differentiation of circulating monocytes into fibrocytes and profibrotic macrophages. PTX2 is a circulating plasma protein that belongs to the class of pattern recognition receptors (PRR) of the innate immune system. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:pentraxin 2
recombinant human PTX2
Code name:PRM-151