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Cuadro 2. Comparación de los regímenes de dosificación pediátricos de la quimioterapia con PEB y JEB
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Régimen
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Bleomicina
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Etopósido
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Cisplatino
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Carboplatino
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Bibliografía
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| PEB pediátrico (cada 21 días) |
15 unidades/m², día 1 |
100 mg/m², días 1-5 |
20 mg/m², días 1-5 |
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[6,7] |
| JEB pediátrico (cada 21-28 días) |
15 mg/m², día 1 |
120 mg/m², días 1-3 |
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600 mg/m² ó 6 mg/ml/min., día 2 |
[8] |
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Bibliografía
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Rogers PC, Olson TA, Cullen JW, et al.: Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol 22 (17): 3563-9, 2004.
[PUBMED Abstract]
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Cushing B, Giller R, Cullen JW, et al.: Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol 22 (13): 2691-700, 2004.
[PUBMED Abstract]
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Mann JR, Raafat F, Robinson K, et al.: The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18 (22): 3809-18, 2000.
[PUBMED Abstract]
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