Cuadro 4. Comparación de los programas pediátricos de dosificación de la quimioterapia con PEB y JEBa
| Régimen | Bleomicina | Etopósido | Cisplatino | Carboplatino | Bibliografía |
| PEB pediátrico (cada 21 días) | 15 unidades/m², día 1 | 100 mg/m², días 1–5 | 20 mg/m², días 1–5 | [6,7] | |
| JEB pediátrico (cada 21–28 días) | 15 unidades/m², día 3 | 120 mg/m², días 1–3 | 600 mg/m² o dosis basada en TFG, día 2 | [8] | |
| TFG = tasa de filtración glomerular; JEB = carboplatino, etopósido y bleomicina; PEB = cisplatino, etopósido y bleomicina. | |||||
| aLas dosis en adultos de la quimioterapia PEB y JEB son diferentes a las dosis pediátricas. | |||||
Bibliografía
- Rogers PC, Olson TA, Cullen JW, et al.: Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol 22 (17): 3563-9, 2004. [PUBMED Abstract]
- Cushing B, Giller R, Cullen JW, et al.: Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol 22 (13): 2691-700, 2004. [PUBMED Abstract]
- Mann JR, Raafat F, Robinson K, et al.: The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18 (22): 3809-18, 2000. [PUBMED Abstract]
