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Some patients with advanced melanoma have had dramatic responses to a new class of targeted drugs in early stage clinical trials. While the long-term effects of these drugs, called BRAF inhibitors, are not yet known, two reports suggest that these drugs may have unintended consequences in patients whose tumors lack mutations in the BRAF gene.
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The symptoms are fairly nonspecific and the disease is rare
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Giving the drug before and after surgery may reduce tumor growth and recurrence
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Autoantibodies found in patients with cancer but not in healthy control subjects
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Finding may explain why some patients with good prognosis still don't fare well

by Dr. Lenora Johnson
We all know the cliché, but it's true nevertheless: We live in a small world, one that seems to get smaller with each new technological advance. Almost immediately after the tragic earthquake in Haiti, for instance, smart phones, Twitter feeds, and blogs were literally buzzing with the news, and almost as quickly people responded with aid, often using these same communication tools. Even now, in the midst of record snow storms blanketing the nation's capital, NCI's ability to communicate vital information is hardly affected. Read more > >
Selected articles from past issues of the NCI Cancer Bulletin are available in Spanish.
The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI), which was established in 1937. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.
For more information about cancer, call 1-800-4-CANCER or visit http://www.cancer.gov.
NCI Cancer Bulletin staff can be reached at ncicancerbulletin@mail.nih.gov.