NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- paclitaxel albumin-stabilized nanoparticle formulation
A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms: Albumin-Stabilized Nanoparticle Paclitaxel
nanoparticle albumin-bound paclitaxel
US brand name: Abraxane Code name: ABI-007