NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

chlorozotocin
A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Chlorozotocyna
D-glucopyranose
Abbreviations:CLZ
CZT
DCNU
Chemical structures:1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea
2-[[[(2-chloroethyl)nitrosamino]carbonyl]amino]-2-deoxy-D-glucose
2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose
D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy
D-glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)