NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

vindesine
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Compound 112531
deacetyl vinblastine carboxamide
desacetylvinblastine amide
US brand name:Eldisine
Abbreviations:DAVA
DVA
VDS
Code name:Lilly CT-3231
Chemical structure:3-(aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine