NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: Compound 112531
deacetyl vinblastine carboxamide
US brand name: Eldisine Abbreviation: DAVA
Code name: Lilly CT-3231 Chemical structure: 3-(aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine