NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

amifostine trihydrate
The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Aminopropylaminoethylthiophosphoric Acid
US brand name:Ethyol
Foreign brand name:Cytofos
Code names:WR-2721
Chemical structures:2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester
S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid
S-2-(3-Aminopropylamino)ethylphosphorothioic Acid