NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

cyclophosphamide
Patient Information
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:(-)-cyclophosphamide
Ciclofosfamida
Ciclofosfamide
Claphene
CP monohydrate
CPM
Cyclophospham
Cyclophosphamid monohydrate
Cyclophosphamidum
Cyclophosphan
Cyclophosphanum
Cytophosphane
Mitoxan
Syklofosfamid
Zytoxan
US brand name:Clafen
Cytoxan
Neosar
Revimmune
Foreign brand name:Carloxan
Cicloxal
Cycloblastin
Cycloblastine
CYCLO-cell
Cyclophosphane
Cyclostin
Cyclostine
Cytophosphan
Endoxan
Endoxana
Enduxan
Fosfaseron
Genoxal
Genuxal
Ledoxina
Procytox
Sendoxan
Abbreviation:CTX
Code name:Asta B 518
B-518
WR-138719
Chemical structure:
  • 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate
  • 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate
  • 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate
  • 2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate
  • 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide
  • 2H-1,3,2-oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
  • bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate
  • bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
  • N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate
  • N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide
  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate
  • N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate
  • N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
  • N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate