NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms: Calcium levoleucovorin
US brand name: Isovorin Foreign brand name: Elvorine, Isovorin, Levofolene, Levorin Abbreviation: L-CF Code name: CL-307,782 Chemical structure: L-5-Formyltetrahydrofolate