NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

hydroxyurea
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:HYD
Hydroxycarbamide
Hydurea
US brand names:Droxia
Hydrea
Foreign brand names:Litalir
Onco-Carbide
Oxeron
Syrea
Abbreviation:HU
Code names:SQ-1089
WR 83799