NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

cladribine
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:Cladribina
US brand name:Leustatin
Foreign brand names:Leustat
Leustatine
Abbreviations:2CDA
2-CdA
Code name:RWJ-26251
Chemical structures:2-chloro-2-deoxyadenosine
2-chlorodeoxyadenosine