NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

methotrexate
Patient Information An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:alpha-methopterin
amethopterin
Methotrexatum
methylaminopterin
Metotrexato
US brand names:Abitrexate
Folex
Folex PFS
Methotrexate LPF
Mexate
Mexate-AQ
Foreign brand names:Brimexate
Emtexate
Emthexat
Emthexate
Farmitrexat
Fauldexato
Lantarel
Ledertrexate
Lumexon
Maxtrex
Medsatrexate
Metex
Methoblastin
Metrotex
Novatrex
Texate
Tremetex
Trexeron
Trixilem
Abbreviation:MTX
Code names:CL-14377
WR-19039
Chemical structures:4-amino-10-methylfolic acid
4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid