NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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oxaliplatin
Patient Information
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Ai Heng
Aiheng
diaminocyclohexane oxalatoplatinum
oxalatoplatin
oxalatoplatinum
oxaliplatine
US brand name:Eloxatin
Foreign brand name:Dacotin
Dacplat
Eloxatine
Abbreviation:1-OHP
L-OHP
Code name:JM-83
RP-54780
SR-96669
Chemical structure:
  • [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum
  • [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum
  • oxalato (1R,2R-cyclohexanediamine)platinum(II)
  • oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)
  • trans-l DACH oxalatoplatinum
  • trans-l diaminocyclohexane oxalatoplatinum