NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

Patient Information An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:diaminocyclohexane oxalatoplatinum
US brand name:Eloxatin
Foreign brand names:Dacotin
Code names:JM-83
Chemical structures:[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum
oxalato (1R,2R-cyclohexanediamine)platinum(II)
oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)
trans-l DACH oxalatoplatinum
trans-l diaminocyclohexane oxalatoplatinum