NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: Lomustinum US brand name: CeeNU Foreign brand names: Belustin
Abbreviation: CCNU Acronym: CCNU Code names: RB-1509
Chemical structures: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea