NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

mechlorethamine hydrochloride
Patient Information The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:chloramin
chlorethamine HCl
chlorethamine hydrochloride
chlorethazine
chlorethazine hydrochloride
chlormethine
chlormethine hydrochloride
chloromethine HCl
mechlorethamine
mechlorethamine HCl
methylchlorethamine
Mustard
mustargen HCl
mustargen hydrochloride
Mustine
NH-2
N-Lost
US brand name:Mustargen
Foreign brand names:Caryolysine
Cloramin
Erasol
Mustine Hydrochloride
Onco-Cloramin
Abbreviations:HN 2
NM
Acronym:NM
Code name:WR-147650
Chemical structures:bis(2-chloroethyl)methylamine
ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl
methylbis(beta-chloroethyl)amine