NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

human MHC non-restricted cytotoxic T-cell line TALL-104
An allogeneic human cytotoxic T-lymphocyte cell line with potential antineoplastic activity. Human MHC non-restricted cytotoxic T-cell line TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and CD3 but not CD16. Upon administration, human MHC non-restricted cytotoxic T-cell line TALL-104 interacts with tumor cells and activates apoptotic and necrotic pathways, resulting in tumor cell lysis. Endowed with MHC-non-restricted killer activity, these cells are cytotoxic against a broad range of tumor cells, sparing normal cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, potentially enhancing its cytotoxic activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:TALL-104